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Small Drug Uses: Cytotec (Misoprostol) is used to prevent stomach ulcers while you take NSAIDs (e.g., aspirin, ibuprofen, naproxen).

Drug Class and Mechanism: Cytotec is a synthetic prostaglandin. Prostaglandins are natural substances found in the stomach as well as in other organs of the human body. In the stomach, prostaglandins are believed to protect the inner stomach lining from the ulcer-producing effects of acid, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used in the treatment of arthritis and other inflammatory conditions. Scientists now believe that aspirin and NSAIDs produce stomach ulceration mostly by inhibiting the production of prostaglandins in the stomach. Synthetic prostaglandin such as cytotec, given orally, has been shown to protect the stomach lining from ulcerating effects of NSAIDs.

Missed Dose: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects: Nausea or stomach cramps may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Diarrhea is common with cytotec and usually occurs about two weeks after you start taking it, and lasts for about a week. Be sure to keep up your intake of fluids and minerals/electrolytes to prevent dehydration. Persistent diarrhea may sometimes lead to a large loss of your body's water and minerals. Tell your doctor immediately if you develop any of these serious signs of dehydration and mineral imbalance: severe dizziness, decreased amount of urine, mental/mood changes, muscle weakness, slow/irregular heartbeat. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people, using this medication, do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: menstrual problems or irregularities, unusual/heavy vaginal bleeding. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage: Store at or below 77 degrees F (25 degrees C) in a dry place away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

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