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Small Drug Uses: Topamax (Topiramate) is an oral drug that is used to prevent the seizures of epilepsy.
Drug Class and Mechanism: Topamax is an oral drug that is used to prevent the seizures of epilepsy. (It is an anti-epileptic or anti-seizure drug). It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topamax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although topamax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, topamax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that topamax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire.
Warnings Precautions: The following medications, when taken with topamax, increase the risk of kidney stones: acetazolamide (Diamox), dorzolamide (Trusopt), methazolamide (Neptazane), dichlorphenamide (Daranide). Carbamazepine (Tegretol) and phenytoin (Dilantin) markedly decrease the amount of topamax in the body by increasing its elimination from the body. As a result, topamax may lose effectiveness unless doses are increased. Topamax may decrease the amount of estrogen in the body in women taking oral contraceptives, possibly increasing the chances of unwanted pregnancy. Patients with seizure disorders taking anticonvulsant medications, including topamax, may develop nerve toxicity from a chemical, 4'-O-methylpyridoxine, found as a contaminant in some ginkgo preparations. Do not take this medicine if you have had an allergic reaction to it or are allergic to any ingredient in this product. Do not stop using this medicine without first checking with your doctor. Some conditions may become worse when the medicine is suddenly stopped. Keep all doctor and laboratory appointments while you are using this medicine. Laboratory and/or medical tests may be done, such as measuring bicarbonate levels in your blood, before you start taking this medicine and during therapy to monitor for side effects. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are taking this medicine. This medicine will add to the effects of alcohol and other depressants. Ask your doctor or pharmacist if you have questions. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. This medicine may reduce sweating which could raise your body temperature, especially in children. The risk of this serious side effect is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids and dress lightly while in hot climates, or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek immediate medical attention if your body temperature is above normal, or if you have mental or mood changes, headache, or dizziness. Contact your doctor for more details. Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. For women, taking this medicine while you are using birth control pills may decrease the effectiveness of your birth control pills. To prevent pregnancy, use an additional form of birth control while you are taking this medicine. Ask your doctor or pharmacist if you need more information. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is unknown if this medicine is excreted in breast milk. If you are or will be breast-feeding while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
Possible Side Effects: In adults, the most common side effects of topamax are tiredness, dizziness, coordination problems, speech problems, changes in vision or double vision, difficulty with memory, and sensory distortion. In children, the most common side effects are drowsiness, tiredness, loss of appetite, nervousness, difficulty with concentration/attention, weight decrease, aggressive reaction and difficulty with memory. Since topamax was approved, there have been 23 cases reported (as of 8-17-01) of a sudden onset of vision and eye problems. Symptoms have typically occurred within the first month of therapy, with patients reporting an acute onset of decreased vision and/or eye pain. Eye examination revealed myopia (nearsightedness), redness, decreased depth of the anterior chamber of the eye and elevated ocular pressure, with or without dilation of the pupils. Fluid accumulation within the eye may displace the lens and iris anteriorly causing secondary angle closure glaucoma. If patients develop this syndrome, the treatment is to discontinue topamax as rapidly as possible, according to the judgment of the treating physician.
More Information: Laboratory and or medical tests (e.g., eye exams) may be performed to monitor your progress. Dc with others for whom it was not prescribed. Do not use this medicine for other health conditions. Keep this medicine out of the reach of children. If using this medicine for an extended period of time, obtain refills before your supply runs out.
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Most cases of ACC of the breast do not spread to the lymph nodes and rarely metastasize to other parts of the body. Not all cases of ACC are fueled by estrogen or progesterone, but some may be hormone-sensitive. ACC can be effectively treated, with very little risk of recurrence, and have an excellent outlook for complete recovery.
Long-Term General Effects. In general, the long-term effects of seizures vary widely depending on the seizure's cause. The long-term outlook for children with idiopathic epilepsy (epilepsy of unknown causes) is very favorable. One study reported that 68 - 92% of these patients were seizure-free after 20 years. Another study reported that they had a survival rate no different from children without these seizures... Topamax Purchase
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Lennox-Gastaut Syndrome. Lennox-Gastaut syndrome is a severe form of epilepsy in young children that causes multiple seizures and some developmental retardation. It usually involves absence, tonic, and partial seizures.
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